Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.
Searching Both is inclusive of interventional and observational studies.
|Eligible Ages||N/A and Over|
Inclusion Criteria:- All patients presenting a MSI CRC (second or third state, histologically confirmed) who have been operated at Saint Antoine Hospital between 1998 and 2013 - Clinical data of patients follow-up available on site - non-opposition for tumour samples using from patient obtained
Exclusion Criteria:- non-opposition for tumour samples using from patient not obtained
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.
Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.
Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.
Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.
|Assistance Publique - Hôpitaux de Paris|
The person who is responsible for the scientific and technical direction of the entire clinical study.
|Principal Investigator Affiliation||N/A|
Category of organization(s) involved as sponsor (and collaborator) supporting the trial.
The disease, disorder, syndrome, illness, or injury that is being studied.
|Colorectal Cancer, Microsatellite Instability|
- - To identify exon/intron junctions that are specifically affected by aberrant splicing events in MSI CRC.
- - PRTK 2014 17/51 process will abide by several rules to minimise the potential to disturb the quantification of expression level in forthcoming analyses.
- - To investigate for functional links between MSI and aberrant splicing events.
- - PRTK 2014 18/51 RT-PCR using internal, specific probes (Applied biosystems).
- - To identify splicing events and/or LNCR mutations with clinical relevance in MSI CRC patients.
- - PRTK 2014 19/51 other known clinical determinants such as stage, treatment and age at diagnosis will be considered in the multivariate models.
- - PRTK 2014 20/51 mRNA level.
- - To initiate functional studies on a limited number of clinically relevant, cancer related genes whose splicing is highly perturbed in MSI cancer cells, and to develop biological tools to simplify screening in future clinical assays.
- - PRTK 2014 21/51 retrospectively from the Pathology Department of Saint-Antoine hospital.
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.